the value of serum nr2 antibody in prediction of post-cardiopulmonary resuscitation survival
نویسندگان
چکیده
introduction: n-methyl-d-aspartate receptor subunits antibody (nr2-ab) is a sensitive marker of ischemic brain damage in clinical circumstances, such as cerebrovascular accidents. we aimed to assess the value of serum nr2-ab in predicting the post-cardiopulmonary resuscitation (cpr) survival. methods: in this cohort study, we examined serum nr2-ab levels 1 hour after the return of spontaneous circulation (rosc) in 49 successfully resuscitated patients. patients with traumatic or asphyxic arrests, prior neurological insults, or major medical illnesses were excluded. participants were followed until death or hospital discharge. demographic data, coronary artery disease risk factors, time before initiation of cpr, and cpr duration were documented. in addition, glasgow coma scale (gcs), blood pressure, and survival status of patients were recorded at 1, 6, 24, and 72 hour(s) after rosc. descriptive analyses were performed, and the cox proportional hazard model was applied to assess if nr2-ab level is an independent predictive factor of survival. results: 49 successfully resuscitated patients were evaluated; 27 (55%) survived to hospital discharge, 4 (8.1%) were in vegetative state, 10 (20.4%) were physically disabled, and 13 (26.5%) were physically functional. within 72 hours of rosc all of the 12 nr2-ab positive patients died. in contrast, 31 (84%) of the nr2-ab negative patients survived. sensitivity, specificity, positive and negative likelihood ratios of nr2-ab in prediction of survival were 54.5% (95%ci=32.7%-74.9%), 100% (95%ci=84.5%-100%), infinite, and 45.5% (95%ci=28.8%-71.8%), respectively. subsequent analysis showed that both nr2-ab status and gcs were independent risk factors of death. conclusions: a positive nr2-ab serum test 1 hour after rosc correlated with lower 72-hour survival. further studies are required to validate this finding and demonstrate the value of a quantitative nr2-ab assay and its optimal time of measurement.
منابع مشابه
The Value of Serum NR2 Antibody in Prediction of Post-Cardiopulmonary Resuscitation Survival
INTRODUCTION N-methyl-D-aspartate receptor subunits antibody (NR2-ab) is a sensitive marker of ischemic brain damage in clinical circumstances, such as cerebrovascular accidents. We aimed to assess the value of serum NR2-ab in predicting the post-cardiopulmonary resuscitation (CPR) survival. METHODS In this cohort study, we examined serum NR2-ab levels 1 hour after the return of spontaneous c...
متن کاملPredictors of Long-Term Survival after Cardiopulmonary Resuscitation
Abstract Introduction: Survival after cardiac arrest is one of the most important issues related to the safety and quality of patient care, and unexpected events such as failure to follow guidelines can endanger the patient's safety. Objective: This study aimed to determine the long-term survival after cardiopulmonary resuscitation and its predictors in patients with cardiac arrest. Materi...
متن کاملnetwork of phonological rules in lori dialect of andimeshk: a study within the framework of post-generative approach.
پژوهش حاضر ارائه ی توصیفی است از نظام آوایی گویش لری شهر اندیمشک، واقع در شمال غربی استان خوزستان. چهارچوب نظری این پژوهش، انگاره ی پسازایشی جزءمستقل می باشد. این پایان نامه شامل موارد زیر است: -توصیف آواهای این گویش به صورت آواشناسی سنتی و در قالب مختصه های زایشی ممیز، همراه با آوانوشته ی تفصیلی؛ -توصیف نظام آوایی گویش لری و قواعد واجی آن در چهارچوب انگاره ی پسازایشی جزءمستقل و معرفی برهم کن...
the effect of oxytetracycline on serum calcium, phosphorus and magnesium in cattle
نتایج این مطالعه نشان می دهد که مقدار کلسیم (یونیزه و تام)، منیزیم و فسفر به طور معنی داری تغییر پیدا کرد به جزء مقدار کلسیم تام و منیزیم در روش داخل عضلانی که تغییر معنی داری نداشته است. بر اساس نتایج این مطالعه می توان نتیجه گیری کرد که اکسی تتراساکلین بر روی مقادیر سرمی کلسیم و منیزیم تأثیر می گذارد باید مقدار این کاتیون ها در بیماران، در هنگامی که اکسی تتراسایکلین استفاده می شود مورد توجه ق...
15 صفحه اولOutcomes of cardiopulmonary resuscitation in the emergency department
Objective: Cardiopulmonary resuscitation (CPR) is a lifesaving technique useful in the prevention of death or delaying it in a person with cardiac arrest. In this regard, demographic information about patients who need CPR is vital. Methods: In this cross-sectional study patients with cardiopulmonary arrest or arrhythmias admitted to Imam Reza and Sina ed...
متن کاملthe effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)
cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...
منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
emergency journalجلد ۳، شماره ۳، صفحات ۸۹-۹۴
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023